Aptamers for pharmaceuticals and their application in environmental analytics
نویسندگان
چکیده
Aptamers are single-stranded DNA or RNA oligonucleotides, which are able to bind with high affinity and specificity to their target. This property is used for a multitude of applications, for instance as molecular recognition elements in biosensors and other assays. Biosensor application of aptamers offers the possibility for fast and easy detection of environmental relevant substances. Pharmaceutical residues, deriving from human or animal medical treatment, are found in surface, ground, and drinking water. At least the whole range of frequently administered drugs can be detected in noticeable concentrations. Biosensors and assays based on aptamers as specific recognition elements are very convenient for this application because aptamer development is possible for toxic targets. Commonly used biological receptors for biosensors like enzymes or antibodies are mostly unavailable for the detection of pharmaceuticals. This review describes the research activities of aptamer and sensor developments for pharmaceutical detection, with focus on environmental applications.
منابع مشابه
Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers
Recent clinical trials of small interfering RNAs (siRNAs) highlight the need for robust delivery technologies that will facilitate the successful application of these therapeutics to humans. Arguably, cell targeting by conjugation to cell-specific ligands provides a viable solution to this problem. Synthetic RNA ligands (aptamers) represent an emerging class of pharmaceuticals with great potent...
متن کاملApplication of Big Data Analytics in Power Distribution Network
Smart grid enhances optimization in generation, distribution and consumption of the electricity by integrating information and communication technologies into the grid. Today, utilities are moving towards smart grid applications, most common one being deployment of smart meters in advanced metering infrastructure, and the first technical challenge they face is the huge volume of data generated ...
متن کاملA Biotechnological Perspective on The Affinity Magnetic Separation and Purification Based on Oligonucleotides
The rapidly growing field of biotechnology has created a critical need for simple, fast andhigh-throughput processes for the separation and purification of biomolecules from biologicalmatrices. In recent years, several bioseparation techniques have been proposed as advancedalternatives to the classical separation methods. These modern processes emphasize ultrahighselective and sensitive analysi...
متن کاملRemoval of Pharmaceutical Compounds from Hospital Wastewaters Using Nanomaterials: A Review
Over the past few years, residual pharmaceuticals (antibiotics, anticonvulsants, antipyretics drugs, hormones) have begun to be considered as emerging environmental pollutants due to their continuous input and persistence to aquatic ecosystem even at low concentrations. Therefore, the development of efficient, cost-effective, and stable methods and materials for the wastewaters treatment have g...
متن کاملAptamers in Bordeaux, 24–25 June 2016
The symposium covered the many different aspects of the selection and the characterization of aptamers as well as their application in analytical, diagnostic and therapeutic areas. Natural and artificial riboswitches were discussed. Recent advances for the design of mutated polymerases and of chemically modified nucleic acid bases that provide aptamers with new properties were presented. The po...
متن کامل